• Get Equipped With -B- - If the player has [Megahand] , enables Bubble Lead mode on [Megahand] , which fires [Bubble Blaster] shots while uncharged. Modes can be switched by reloading the [Megahand] with a full magazine.
• Hydro Pump - If the player also has [Escape Rope] , damage is increased by 50%, shot speed and knockback is tripled, and stream size is increased.
• Ice Water - If the player has [Snowballer] , Mega Douser freezes enemies, leaves ice, and both guns deal 30% more damage.
• Napalm B - If the player has [Napalm Strike] , Mega Douser will spread fire instead of dousing it. With this synergy, the water pool will be flammable like oil, but will be crisscrossed by lines of dry floor that prevent the fire from spreading too far. Spraying the same area will rearrange the dry lines, spreading the fire further.
• When paired with weapons such as [Shock Rifle] it can create huge pools of electrified water and damage most enemies in a room. This technique is effective against bosses as well. [Battery Bullets] will immediately electrify the pool, making it an extremely powerful gun for The Robot .
• The Mega Douser's beam won't automatically electrify the pool it creates with [Battery Bullets] .
• Can be used to put out the fireplace as well as the fuse on Chests .
• [Bouncy Bullets] can cause the stream of water to fragment and bounce, covering nearly the whole room in overlapping streams of water.
• If the Hydro Pump synergy is active, Roll Bombs will have their size increased as well while Mega Douser is held.
• if the Hydro Pump synergy is active in Co-op mode, and when one player has the escape rope and the other has the Mega Douser, the bullets the player fires will be increased in size.
• If the player has the Hydro Pump synergy and dodge rolls with the [Cat Bullet King Throne] , the bullets fired by the throne will also be doubled in size. This only happens when the Mega Douser is held.

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