• Alas, Sniperion - If the player also has [Crescent Crossbow] , Crown of Guns becomes Sailor Moon's tiara and shoots crescent shaped bullets that do more damage.
• Blast Crown - If the player has [Blast Helmet] , Crown of Guns gains a chance to fire explosives.
• Great Queen Ant - If the player has [Gungeon Ant] , it turns into an ant queen that fires rocket ants.
• King Bomber - If the player has [Lil' Bomber] , its bombs spawn every time they hit an enemy.
• Poseigun - If the player has [Trident] , Crown of Guns randomly fires [Trident] beams, while [Trident] fires a spread of three beams per shot, no longer benefits from rolling, has its magazine size decreased to 8, and has its fire rate reduced greatly.
• Two Heavy - If the player also has [Coin Crown] , the chance for [Coin Crown] to spawn money upon clearing a room is doubled.
• Usurper - If the player has [Cat Bullet King Throne] , the Crown fires more rapidly and also automatically charms Bullet Kin and Veteran Bullet Kin when held. This charm effect seems to persist on the Bullet Kins after it activates, even if you switch your gun afterwards.
• If the player also has [Backup Gun] , bullet output is doubled.
• Taping the Crown of Guns to another gun using [Duct Tape] will cause each shot to expend 4 ammo instead of the normal 2, due to the Crown of Guns firing three shots at once.
• Combining this gun with [Remote Bullets] makes this gun very potent against bosses and standard rooms alike, as all bullets are redirected to your cursor's direction.
• Combining this gun with [Shock Rounds] also makes this gun extremely potent against bosses, as the bullets become impossible to dodge.
• Combining this gun with [Chance Bullets] makes this gun fire your other guns at an incredibly high rate
• Combining this gun with [Crutch] will strengthen its bullets' homing abilities, adding to the gun's inherent homing
• This gun works especially well with the [Black Hole Gun] by shooting the [Black Hole Gun] at an enemy and then shooting the Crown of Guns.
• This gun's functionality can be described as a rapid fire, 3-shot shotgun with 360 degree spread. This means that items that increase accuracy will work as expected on it, decreasing its full circle spread to a smaller cone. Stacking such items will further decrease the spread of the gun, eventually causing its performance to more closely resemble guns such as the [Vulcan Cannon] .
• Conversely, as long as you don't have any accuracy increasing items, [Eyepatch] has effectively no downside on this gun and acts as a flat damage boost.

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